Some toxic Impact of Digoxin in mice

International Conference on Materials Engineering and Science

Jaafar, Farrah R.^1

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq^1

关键词: Aminotransferase;    Aspartate aminotransferase;    Digoxin;    Distilled water;    mice;    Some toxic;    Therapeutic dose;    Treatment group;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/454/1/012114/pdf
DOI  :  10.1088/1757-899X/454/1/012114

来源: IOP

【 摘 要 】

The present study was designed to evaluate the toxic effect of digoxin on liver in biochemically by measuring liver transaminase enzymes level in the serum, gross lesion and Toxic signs in mice . The toxicity study was carried out on Three treatment groups, each consist of 10 mice divided according to daily treatment with digoxin to T1, T2 & C representing dosing orally with 5, 10 mcg/kg respectively the three group act as control and treated with distilled water in 21 day. The result showed significant (p1 and T2 groups when compared with contral groups in positively proportional with the dose of digoxin. Yellow of spots was noticed in the liver in T2 groups at the end of experiment. Toxic signs were also noticed increase proportionally with the dose of treated group including: Depression, Weakness, Extended body, In-coordination, Anorexia . In conclusion this study revealed that digoxin of both dose 5mcg/kg and10 mcg/kg in caused some toxic signs and toxic effect on liver tissue effect propotinal with the dose and period of expouser even at the therapeutic dose that indicate the precaution in using such drug.