A vascular fabrication method based on sacrificial material and spraying process

2018 5th International Conference on Advanced Composite Materials and Manufacturing Engineering

Qi, Jian^1 ; Li, Jia^1 ; Zheng, Shuxian^1 ; Liu, Jie^1

Tianjin Key Laboratory of Equipment Design and Manufacturing Technology, School of Mechanical Engineering, Tianjin University, Tianjin

300354, China^1

关键词: Fabrication method;    Gel materials;    High pressure air;    Orthogonal experiment;    Poly (vinyl alcohol) (PVA);    Sacrificial material;    Spraying process;    Vascular structures;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/394/2/022061/pdf
DOI  :  10.1088/1757-899X/394/2/022061

来源: IOP

【 摘 要 】

In tissue engineering, the lack of vascular structures often leads to massive cell death inside the scaffold, it is necessary to construct vascular structures in scaffolds. This paper presented a method for fabricating blood vessels based on sacrificial materials and spraying process. Sucrose was used as the sacrificial material to prepare the vascular core, the SA/PVA gel formulated from sodium alginate (SA) and polyvinyl alcohol (PVA) was used as vascular material. The optimal proportion of SA/PVA gel material was determined by orthogonal experiments: SA: 4 wt%, PVA: 5 wt%, CaCl2: 4 wt%, and its elastic modulus and porosity were 993.19 kPa and 89.23%. The spraying process utilized high-pressure air flow to coat the SA/PVA gel on the vascular core, and then it was cross-linked in CaCl2 solution, and the hollow vascular structure can be obtained by removing the vascular core in an aqueous solution. This method allows rapid, low-cost preparation of vascular structures.