Euroinvent ICIR 2018 | |
Theoretical and Experimental Approach Towards P-Cyano Stilbene Schiff Base as a Potential Linker in E-DNA Sensor | |
Yusoff, H.M.^1,2 ; Hassan, N.^1,2 ; Ku Bulat, K.H.^2 | |
Advanced Nanomaterials Research Group, School of Fundamental Science, Universiti Malaysia Terengganu, Terengganu, Kuala Terengganu | |
21030, Malaysia^1 | |
School of Fundamental Science, Universiti Malaysia Terengganu, Kuala Terengganu | |
21030, Malaysia^2 | |
关键词: Electrochemical DNA sensor; Experimental approaches; Fourier transform infrared spectrometer; Geometry optimization; Schiff base compounds; Schiff base molecules; Stretching vibrations; UV-Vis spectrophotometers; | |
Others : https://iopscience.iop.org/article/10.1088/1757-899X/374/1/012086/pdf DOI : 10.1088/1757-899X/374/1/012086 |
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来源: IOP | |
【 摘 要 】
This research aim to synthesis and characterize several p-cyano stilbene Schiff base molecules as a potential linker in electrochemical DNA sensor. Schiff base reaction is form from condensation reaction between primary amine and aldehyde at 79 °C using ethanol as solvent. All compounds are investigated and discussed by Fourier transform-infrared spectrometer (FTIR) and Uv-vis spectrophotometer. For computational study, structure drawings were constructed using GaussView 5.0. Geometry optimization has been carried out using density functional theory (DFT) at bB3LYP/6 31G and performed using Gaussian09 software. FTIR showed formation of C≡N stretching vibrations at 2224 cm-1also another important stretching at 1604 cm-1and 1249 cm-1which represent C=N and C-O mode respectively. In UV-vis, absorbance of C=N (imine) group can be observed at peak range 363 nm and transition of aromatic C=C can be seen at 238 nm. Theoretical and experimental results obtained are comparable and p-cyano stilbene Schiff base compounds were successfully synthesised and can be further applied as a linker in E-DNA sensor.
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