Fabrication of Polyvinylpyrrolidone Fibers by Means of Rotary Forcespinning Method

5th International Conference on Advanced Materials Sciences and Technology

Andjani, D.^1,2 ; Sriyanti, I.^1,2 ; Fauzi, A.^1 ; Edikresnha, D.^1,2 ; Munir, M.M.^1,2 ; Khairurrijal^1,2

Department of Physics, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung

40132, Indonesia^1

Bioscience and Biotechnology Research Center, Institute for Research and Community Services, Institut Teknologi Bandung, Bandung

40132, Indonesia^2

关键词: Active ingredients;    Digital microscopes;    Drug delivery system;    Electrospinning method;    Microscope images;    Poly vinyl pyrrolidone;    Polymer concentrations;    Precursor solutions;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/367/1/012044/pdf
DOI  :  10.1088/1757-899X/367/1/012044

来源: IOP

【 摘 要 】

Fibers made from polymer materials have been widely developed as a carrier medium of active ingredients in drug delivery systems. In this research, PVP polymer was chosen because of its wide and safe use in the medical field. The purpose of this study was to produce PVP fibers that can later be applied as a carrier of active ingredients in drug delivery systems. The rotary forcespinning (RFS) method was chosen to shorten the time of production and to overcome the limitations of electrospinning method such as the use of high voltage and dielectric solutions. The PVP solution was varied in several concentrations (8 wt%, 10 wt%, 12 wt%, 14 wt%, 16 wt%, and 18 wt%) to achieve the best fibers morphology. The morphology and the diameter of fibers were analyzed using a digital microscope. From the microscope images, it can be shown that beaded fibers were formed when the concentration of polymer in the precursor solution was low. The number of beads decreased as the concentration of polymer increased. Beads-free fibers were fully formed at above certain polymer concentration.