Bilayer tablets of Paliperidone for Extended release osmotic drug delivery

14th International Conference on Science, Engineering and Technology

自然科学;工业技术

Sunil Chowdary, K.^1 ; Napoleon, A.A.^1

Chemistry Department, SAS, VIT University, Vellore, Tamil Nadu

632014, India^1

关键词: Cellulose acetates;    Coating solution;    Enteric-coating;    Ethyl cellulose;    Extended release;    In-vitro dissolution;    Osmotic drug delivery;    Release pattern;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/263/2/022020/pdf
DOI  :  10.1088/1757-899X/263/2/022020

来源: IOP

【 摘 要 】

The purpose of this study is to develop and optimize the formulation of paliperidone bilayer tablet core and coating which should meet in vitro performance of trilayered Innovator sample Invega. Optimization of core formulations prepared by different ratio of polyox grades and optimization of coating of (i) sub-coating build-up with hydroxy ethyl cellulose (HEC) and (ii).enteric coating build-up with cellulose acetate (CA). Some important influence factors such as different core tablet compositions and different coating solution ingredients involved in the formulation procedure were investigated. The optimization of formulation and process was conducted by comparing different in vitro release behaviours of Paliperidone. In vitro dissolution studies of Innovator sample (Invega) with formulations of different release rate which ever close release pattern during the whole 24 h test is finalized.