Composite fibrous glaucoma drainage implant

17th World Textile Conference AUTEX 2017 - Shaping the Future of Textiles

Klapstova, A.^1 ; Horakova, J.^1 ; Shynkarenko, A.^2 ; Lukas, D.^1

Technical University of Liberec, Faculty of Textile Engineering, Department of Nonwovens and Nanofibrous Materials, Liberec

461 17, Czech Republic^1

Technical University of Liberec, Faculty of Mechanical Engineering, Department of Manufacturing Systems and Automation, Liberec

461 17, Czech Republic^2

关键词: Electrospinning method;    Fibrous structures;    Glaucoma implant;    Intra ocular pressure;    Liquid transport;    Morphological parameters;    Optic nerve head;    Special properties;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/254/6/062006/pdf
DOI  :  10.1088/1757-899X/254/6/062006

来源: IOP

【 摘 要 】

Glaucoma is a frequent reason of loss vision. It is usually caused by increased intraocular pressure leading to damage of optic nerve head. This work deals with the development of fibrous structure suitable for glaucoma drainage implants (GDI). Commercially produced metallic glaucoma implants are very effective in lowering intraocular pressure. However, these implants may cause adverse events such as damage to adjacent tissue, fibrosis, hypotony or many others [1]. The aim of this study is to reduce undesirable properties of currently produced drains and improve their properties by creating of the composite fibrous drain for achieve a normal intraocular pressure. Two types of electrospinning technologies were used for the production of very small tubular implants. First type was focused for production of outer part of tubular drain and the second type of electrospinning method made the inner part of shape follows the connections of both parts. Complete implant had a special properties suitable for drainage of fluid. Morphological parameters, liquid transport tests and in-vitro cell adhesion tests were detected.