TiO2 Nanotube Arrays Modified With Zinc and Loaded with Hydrophilic and Hydrophobic Drugs

International Conference on Materials Sciences and Nanomaterials

材料科学;物理学

Zhang, Fengfen^1 ; Zhan, Xiaowei^1 ; Yang, Xiaojuan^1 ; Xiao, Xiufeng^1

Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Fujian Normal University, Fuzhou

350007, China^1

关键词: Anodizations;    Burst release;    Hydrophilic and hydrophobic;    Hydrothermal methods;    Release behaviors;    Sustained release;    TiO2 nanotube arrays;    Vacuum drying;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/230/1/012034/pdf
DOI  :  10.1088/1757-899X/230/1/012034

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

TiO2nanotube arrays were prepared by anodization of Ti plat, then modified by hydrothermal method in Zn(NO3)2solution and finally loaded alendronate or ibuprofen drugs by vacuum drying. The experimental results show that the amount of two drugs loaded on the modified TiO2nanotube array is increased. The release behavior of the modified nanotubes including burst release and sustained relase. high hours before release. The modified TiO2nanotube arrays were more slowly released during the sustained release than unmodified nanotubes, indicating that the Zn2+modified nanotubes have certain sustained-release effect.