Formulation and synthesis of hydrogels having lower critical solution temperature near body temperature

Innovation in Polymer Science and Technology 2016

材料科学;化学

Abidin, A.Z.^1 ; Graha, H.P.R.^1 ; Trirahayu, D.A.^1

Department of Chemical Engineering, Faculty of Industrial Technology Institut Teknologi Bandung, Jl. Ganesa 10, Bandung

40132, Indonesia^1

关键词: Bacterial Cellulose Nanocrystals;    Body temperature;    Copolymer solution;    Lower critical solution temperature;    Methyl cellulose;    Salt addition;    Salt content;    Solution viscosity;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/223/1/012043/pdf
DOI  :  10.1088/1757-899X/223/1/012043

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Copolymerization between bacterial cellulose nanocrystal (CN) and methyl cellulose (MC) was carried out using UV light to produce a biocompatible hydrogel at body temperature and liquid at room temperature. Viscosity and salt effect of the MC and copolymer solution at room temperature and its Lower Critical Solution Temperature (LCST) were evaluated. The analysis showed that the higher concentration of methyl cellulose and salt content in the solution produced lower LCST and higher solution viscosity. All samples of polymer solution with MC concentrations of 1 and 2% have a viscosity less than 5000 cP at room temperature. The solutions with MC concentration of 1, 2, and 3% have respectively LCST of 59, 58, and 57°C, while its copolymer solutions with CN concentration of 0.1, 0.3, and 0.5% have respectively LCST of 55, 51, and 41°C. The salt addition to the solution of MC-CN copolymer with concentrations of 1x and 1.5x Phosphat Buffered Saline (PBS) produces respectively LCST of 47 and 38°C. The results suggest that the copolymer solution of MC-CN could produce a lower LCST and the addition of salt could amplify the effect of LCST decrease that can be used to produce a biocompatible hydrogel with LCST as close as body temperature.