Calcium modified edible Canna (Canna edulis L) starch for controlled released matrix

Innovation in Polymer Science and Technology 2016

材料科学;化学

Putri, A.P.^1 ; Ridwan, M.^1 ; Darmawan, T.A.^1 ; Darusman, F.^1 ; Gadri, A.^1

Department of Pharmacy, Bandung Islamic University, Bandung, Indonesia^1

关键词: Compressibility index;    Controlled released;    Cross linking agents;    Dissolution profiles;    Hydroxypropyl methyl cellulose;    Modified starches;    Reference standard;    Water solubilities;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/223/1/012041/pdf
DOI  :  10.1088/1757-899X/223/1/012041

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Canna edulis L starch was modified with calcium chloride in order to form controlled released matrix. Present study aim to analyze modified starch characteristic. Four different formulation of ondansetron granules was used to provide dissolution profile of controlled released, two formula consisted of 15% and 30% modified starch, one formula utilized matrix reference standards and the last granules was negative control. Methocel-hydroxypropyl methyl cellulose was used as controlled released matrix reference standards in the third formula. Calcium starch was synthesized in the presence of sodium hydroxide to form gelatinized mass and calcium chloride as the cross linking agent. Physicochemical and dissolution properties of modified starch for controlled released application were investigated. Modified starch has higher swelling index, water solubility and compressibility index. Three of four different formulation of granules provide dissolution profile of controlled released. The profiles indicate granules which employed calcium Canna edulis L starch as matrix are able to resemble controlled drug released profile of matrix reference, however their bigger detain ability lead to lower bioavailability.