Development and in vitro evaluation of carboxymethyl chitosan based drug delivery system for the controlled release of propranolol hydrochloride

International Conference on Natural Products and Bioresource Science 2017

生物科学;化学

Hernawan^1 ; Hayati, Septi Nur^1 ; Nisa, Khoirun^1 ; Indrianingsih, Anastasia Wheni^1 ; Darsih, Cici^1 ; Kismurtono, Muhammad^1

Research Unit for Natural Products Technology, Indonesian Institute of Sciences, Yogyakarta, Indonesia^1

关键词: Carboxymethyl chitosan;    Controlled release;    Direct compression;    Dissolution profiles;    Drug delivery system;    Extended release;    In-vitro evaluation;    Zero-order models;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/101/1/012038/pdf
DOI  :  10.1088/1755-1315/101/1/012038

学科分类：生物科学（综合）

来源: IOP

【 摘 要 】

Propranolol hydrochloride is a nonselective β-adrenergic drug and has been used as angina pectoris, antihypertensive, and that of many other cardiovascular disorders. It has a relatively short plasma half-life and duration of action are considered too short in certain circumstances. Thus, it's fascinating to elongate the action. The tablet formula was based on extended-release by a propranolol hydrochloride based carboxymethyl chitosan matrix. Here we used direct compression technique with internal wet granulation to prepare the tablets. The tablets were evaluated for physical properties (hardness, weight variation test, friability) and in vitro release studies. There was no interaction observed between propranolol hydrochloride and excipients. Dissolution profiles of each formulation were followed zero order model. In conclusion, these results strongly suggest that in appropriate proportions carboxymethyl chitosan with internal granulation is suitable for formulating propranolol hydrochloride controlled release.