Novel Injectable Calcium Phosphate Bone Cement from Wet Chemical Precipitation Method

2nd International Conference on Materials Engineering and Nanotechnology

材料科学;物理学

Hablee, S.^1 ; Sopyan, I.^1 ; Mel, M.^2 ; Salleh, H.M.^2 ; Rahman, M.M.^3 ; Singh, R.^4

Department of Manufacturing and Materials Engineering, Kulliyyah of Engineering, International Islamic University Malaysia, PO Box 10, Kuala Lumpur

50728, Malaysia^1

Department of Biotechnology Engineering, Kulliyyah of Engineering, International Islamic University Malaysia, PO Box 10, Kuala Lumpur

50728, Malaysia^2

Department of Mechanical Engineering, College of Engineering, Universiti Tenaga Nasional, Jalan IKRAM-UNITEN, Selangor Darul Ehsan, Kajang

43000, Malaysia^3

Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur

50603, Malaysia^4

关键词: Bone filling materials;    Calcium phosphate bone cement;    Calcium phosphate cement;    Chemical precipitation method;    Compression strength;    Di-ammonium hydrogen phosphate;    Synthesized powder;    Wet-chemical precipitation;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/205/1/012012/pdf
DOI  :  10.1088/1757-899X/205/1/012012

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Calcium phosphate cement has been prepared via chemical precipitation method for injectable bone filling materials. Calcium hydroxide, Ca(OH)2, and diammonium hydrogen phosphate, (NH4)2HPO4, were used as calcium and phosphorus precursors respectively. The synthesized powder was mixed with water at different powder-to-liquid (P/L) ratios, which was adjusted at 0.8, 0.9, 1.0, 1.1 and 1.2. The influence of P/L ratio on the injectability, setting time and mechanical strength of calcium phosphate cement paste has been evaluated. The synthesized powder appeared as purely hydroxyapatite with nanosized and agglomerated spherical particles. All cement pastes show excellent injectability except for the paste with P/L ratio 1.2. Calcium phosphate cement with P/L ratio 1.1 shows the ideal cement for bone filler application with good injectability, the initial and final setting times of 30 min and 160 min, and the compression strength of 2.47 MPa. The result indicated that the newly developed calcium phosphate cement is physically suitable for bone filler application. This paper presents our investigation on the effect of P/L ratio on the handling and mechanical properties of calcium phosphate cement prepared via wet chemical precipitation method.