Composite Based Chitosan/Zinc-Doped HA as a Candidate Material for Bone Substitute Applications

4th International Conference on Advanced Materials Science and Technology

Wicaksono, S.T.^1 ; Rasyida, A.^1 ; Purnomo, A.^1 ; Pradita, N.N.^1 ; Ardhyananta, H.^1 ; Hidayat, M.I.P.^1

Department of Materials and Metallurgical Engineering, Faculty of Industrial Technology, Institut Teknologi Sepuluh Nopember (ITS), Surabaya

60111, Indonesia^1

关键词: Bone substitute application;    Cancellous bone;    Candidate materials;    Mechanical characterizations;    Mixing method;    Non-toxic materials;    Physical and mechanical properties;    Surface hardness;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/202/1/012080/pdf
DOI  :  10.1088/1757-899X/202/1/012080

来源: IOP

【 摘 要 】

The composite based Zinc-doped in Chitosan/Hydroxyapatite was successfully prepared by wet mixing method through the addition of 10, 15, and 20wt% of chitosan. The addition of Chitosan increased the compressive strength and the modulus elasticity. However, it decreased the density and the surface hardness of HA-Zn. Mechanical characterization revealed that these composites are suitable as a candidate of a cancellous bone substitute. Composite with 10% chitosan has compressive strength and modulus elasticity of 57.03 MPa and 0.15 GPa, respectively. Hence, it has the physical and mechanical properties that meet the standards as a cancellous bone substitute material. Also, in vitro biocompatibility test against BHK-21 cells exhibited non-toxic materials.