Cinnamomum casia Extract Encapsulated Nanochitosan as Antihypercholesterol

11th Joint Conference on Chemistry in Conjunction with the 4th Regional Biomaterials Scientific Meeting

材料科学;化学;生物科学

Ngadiwiyana^1 ; Purbowatiningrum^1 ; Fachriyah, Enny^1 ; Ismiyarto^1

Chemistry Department, Science and Mathematics Faculty, Diponegoro University, Jl. Prof. H. Soedarto, SH, Tembalang, Semarang, Postcode

50275, Indonesia^1

关键词: Absorption process;    Cardio-vascular disease;    Chitosan nanoparticles;    Cholesterol-lowering effects;    Clinical manifestation;    Encapsulation efficiency;    Particle size analyzers;    UV-vis spectrophotometry;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/172/1/012035/pdf
DOI  :  10.1088/1757-899X/172/1/012035

来源: IOP

【 摘 要 】

Atherosclerosis vascular disease with clinical manifestations such as cardiovascular disease and stroke are the leading cause of death in Indonesia. One solution to these problems is a natural antihypercholesterol medicine by utilizing Cinnamomum casia extract. However, the use of natural extracts to lower blood cholesterol levels do not provide optimal results because it is possible that the active components of extract have been degraded/damaged during the absorption process. So that, we need to do the research to get a combination of chitosan nanoparticles-Cinnamomum casia. extract as a compound which has an antihypercholesterol activity through the in vitro study. Modification of natural extracts encapsulated nanochitosan be a freshness in this study, which were conducted using the method of inclusion. The combination of both has the dual function of protecting the natural extracts from degradation and deliver the natural extracts to the target site. Analysis of nanochitosan using the Particle Size Analyzer (PSA) shows the particle size of synthesis product that is equal to 64.9 nm. Encapsulation efficiency of Cinnamomum casia extract-Chitosan Nanoparticles known through UV-VIS spectrophotometry test and obtained the efficiency encapsulation percentage of 84.93%. Zeta Potential at 193,3 mv that chitosan appropriate for a delivery drug. Antihypercholesterol activity tested in vitro assay that showed the extract-nanoparticle chitosan in concentration 150 ppm gave the highest cholesterol decreasing level in the amount of 49.66% w/v. So it can be concluded that Cinnamomum casia extract can be encapsulated in nanoparticles of chitosan and proved that it has a cholesterol-lowering effect through the in vitro study.