Prospects of paramagnetic lanthanide complexes for magnetic resonance imaging, local thermosensing and diagnosing

3rd International Conference and Young Scientist School "Magnetic resonance imaging in biomedical research"

物理学;医药卫生

Babailov, S.^1 ; Akulov, A.^2,3 ; Moshkin, M.^3 ; Koptyug, I.^4

Nikolayev Institute of Inorganic Chemistry, Russian Academy of Sciences, Novosibirsk, Russia^1

Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia^2

Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia^3

International Tomography Centre, Russian Academy of Sciences, Novosibirsk, Russia^4

关键词: Biology and medicine;    Lanthanide-induced shifts;    NMR spectrometer;    Paramagnetic lanthanide complexes;    Paramagnetic properties;    Practical importance;    Temperature dependencies;    Thermo sensitive;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/886/1/012003/pdf
DOI  :  10.1088/1742-6596/886/1/012003

学科分类：卫生学

来源: IOP

【 摘 要 】

The features of the paramagnetic properties of lanthanide (Ln) containing complexes with crown ethers, pivaloyltrifluoracetonato, and EDTA have been studied by 1H and 19F NMR techniques. These complexes are of interest due to the prospect of using some of them as sensors for biology and medicine. The temperature dependencies of the lanthanide-induced shifts revealed that Ln complexes might have practical importance for 1H and 19F NMR temperature control in solutions. It was shown in vitro (using NMR spectrometers and MRI scanners) that these complexes can serve as special NMR thermo-sensitive contrast reagents.