Characterization of novel preclinical dose distributions for micro irradiator

9th International Conference on 3D Radiation Dosimetry

Kodra, J.^1 ; Miles, D.^1 ; Yoon, S.W.^1 ; Kirsch, D.G.^1 ; Oldham, M.^1

Dept. of Radiation Oncology, Duke University Medical Center, Durham

NC, United States^1

关键词: 3-D printing;    Dose distributions;    High resolution;    Morphic;    Pre-clinical;    Small animal study;    Small scale;    Sub-millimeter resolutions;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/847/1/012054/pdf
DOI  :  10.1088/1742-6596/847/1/012054

来源: IOP

【 摘 要 】

This work explores and demonstrates the feasibility of utilizing new 3D printing techniques to implement advanced micro radiation therapy for pre-clinical small animal studies. 3D printed blocks and compensators were designed and printed from a strong x-ray attenuating material at sub-millimeter resolution. These techniques enable a powerful range of new preclinical treatment capabilities including grid therapy, lattice therapy, and IMRT treatment. At small scales, verification of these treatments is exceptionally challenging, and high resolution 3D dosimetry (0.5mm3) is an essential capability to characterize and verify these capabilities, Here, investigate the 2D and 3D dosimetry of several novel pre-clinical treatments using a combination of EBT film and Presage/optical-CT 3D dosimetry in rodent-morphic dosimeters.