Mitochondrial respiration inhibition after exposure to UWB pulses as a possible mechanism of antitumor action

5th International Congress on Energy Fluxes and Radiation Effects 2016

Zharkova, L.^1,2 ; Romanchenko, I.^2 ; Bolshakov, M.^1,2 ; Rostov, V.^1,2

National Research Tomsk State University, Tomsk, Russia^1

Institute of High Current Electronics SB RAS, Tomsk, Russia^2

关键词: Centre frequency;    Electrical resistances;    Inhibitory effect;    Mitochondrial membranes;    Mitochondrial respiration;    Oxygen consumption;    Possible mechanisms;    Respiratory control;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/830/1/012010/pdf
DOI  :  10.1088/1742-6596/830/1/012010

来源: IOP

【 摘 要 】

The respiration of isolated mice liver mitochondria after exposure to nanosecond UWB pulses (0.15 - 36 kV/cm, 0.6 - 1.0 GHz centre frequency, 3 - 20 ns pulse duration) has been investigated. The respiratory control (RC, the ratio of oxygen consumption) was estimated. The possibility of mitochondrial membrane electroporation was detected as the decrease in the electrical resistance, according to the β-dispersion of the electric current. The monotonous decrease of RC after 1000 UWB pulses from 0.15 kV/cm was observed, the ohmic resistance of mitochondria suspension was reduced. The obtained data indicate the inhibitory effect of UWB pulses on a state of irradiated mitochondria and its membrane.