On the use of fractional order PK-PD models

13th European Workshop on Advanced Control and Diagnosis

Ionescu, Clara^1 ; Copot, Dana^1

Ghent University, Faculty of Engineering and Architecture, Research Group on Dynamical Systems and Control (DySC), Technologiepark 914, Ghent

B9052, Belgium^1

关键词: Control techniques;    Depth of anesthesia;    Fractional calculus;    Fractional order;    Linear controls;    Measurement technologies;    Novel interpretation;    Sensor techniques;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/783/1/012050/pdf
DOI  :  10.1088/1742-6596/783/1/012050

来源: IOP

【 摘 要 】

Quantifying and controlling depth of anesthesia is a challenging process due to lack of measurement technology for direct effects of drug supply into the body. Efforts are being made to develop new sensor techniques and new horizons are explored for modeling this intricate process. This paper introduces emerging tools available on the 'engineering market' imported from the area of fractional calculus. A novel interpretation of the classical drug-effect curve is given, enabling linear control. This enables broadening the horizon of signal processing and control techniques and suggests future research lines.