Measuring synchronization of stochastic oscillators in biology

29th Workshop on Recent Developments in Computer Simulation Studies in Condensed Matter Physics

物理学;计算机科学

Deng, Z.^1 ; Arsenault, S.^2 ; Mao, L.^2 ; Arnold, J.^3

College of Engineering, University of Georgia, United States^1

Institute of Bioinformatics, Entomology Department, University of Georgia, United States^2

Genetics Department, University of Georgia, United States^3

关键词: Intraclass correlations;    Phase-locking models;    Single cells;    Statistical framework;    Stochastic oscillators;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/750/1/012001/pdf
DOI  :  10.1088/1742-6596/750/1/012001

学科分类：计算机科学（综合）

来源: IOP

【 摘 要 】

A fundamental problem in physics is measuring and modeling the synchronization of coupled stochastic oscillators. The problem is relatively recent in biology, where it has become possible to measure stochastic oscillators in single cells. A variety of synchronization measures have been proposed to describe a field of coupled stochastic oscillators. We introduce a synchronization measure new to this problem (but old to Genetics) called the intraclass correlation (ICC). The ICC is simple to interpret and has a statistical framework for inference. We illustrate ICC behaviour in the Kuramoto phase-locking model and on a field of over 25,000 oscillators in single cells measured every half-hour over a ten day interval.