5th International Conference of Photonics and Information Optics | |
Nanodiamonds + bacteriochlorin as an infrared photosensitizer for deep-lying tumor diagnostics and therapy | |
Sharova, A.S.^1 ; Maklygina, Yu S.^2 ; Lisichkin, G.V.^3 ; Mingalev, P.G.^3 ; Loschenov, V.B.^1,2 | |
National Research Nuclear University MEPhI, Moscow Engineering Physics Institute, 31 Kashirskoe shosse, Moscow | |
115409, Russia^1 | |
A.M. Prokhorov General Physics Institute, Russian Academy of Science, Vavilov str.38, Moscow | |
119991, Russia^2 | |
Lomonosov Moscow State University (MSU), Chemical Faculty, Moscow | |
119991, Russia^3 | |
关键词: Absorption and fluorescence spectra; Deep-lying tumors; Diamond nano-particles; Functional nanostructures; Size distribution spectra; Spectroscopic property; Surface layers; | |
Others : https://iopscience.iop.org/article/10.1088/1742-6596/737/1/012052/pdf DOI : 10.1088/1742-6596/737/1/012052 |
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来源: IOP | |
【 摘 要 】
The spectroscopic properties of potentially perspective nanostructure: diamond nanoparticles with a surface layer of IR-photosensitizer, bacteriochlorin, were experimentally investigated in this study. Such specific structure of the object encourages enhancement of the drug tropism to the tumor, as well as increasing of photodynamic penetration depth. The size distribution spectra of diamond nanoparticles; diamond nanoparticles, artificially covered with bacteriochlorin molecules layer, in aqueous solution, were obtained during the study. Based on the absorption and fluorescence spectra analysis, the benefits of functional nanostructure as a drug for deep-lying tumor diagnostics and therapy were reviewed.
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