Nanodiamonds + bacteriochlorin as an infrared photosensitizer for deep-lying tumor diagnostics and therapy

5th International Conference of Photonics and Information Optics

Sharova, A.S.^1 ; Maklygina, Yu S.^2 ; Lisichkin, G.V.^3 ; Mingalev, P.G.^3 ; Loschenov, V.B.^1,2

National Research Nuclear University MEPhI, Moscow Engineering Physics Institute, 31 Kashirskoe shosse, Moscow

115409, Russia^1

A.M. Prokhorov General Physics Institute, Russian Academy of Science, Vavilov str.38, Moscow

119991, Russia^2

Lomonosov Moscow State University (MSU), Chemical Faculty, Moscow

119991, Russia^3

关键词: Absorption and fluorescence spectra;    Deep-lying tumors;    Diamond nano-particles;    Functional nanostructures;    Size distribution spectra;    Spectroscopic property;    Surface layers;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/737/1/012052/pdf
DOI  :  10.1088/1742-6596/737/1/012052

来源: IOP

【 摘 要 】

The spectroscopic properties of potentially perspective nanostructure: diamond nanoparticles with a surface layer of IR-photosensitizer, bacteriochlorin, were experimentally investigated in this study. Such specific structure of the object encourages enhancement of the drug tropism to the tumor, as well as increasing of photodynamic penetration depth. The size distribution spectra of diamond nanoparticles; diamond nanoparticles, artificially covered with bacteriochlorin molecules layer, in aqueous solution, were obtained during the study. Based on the absorption and fluorescence spectra analysis, the benefits of functional nanostructure as a drug for deep-lying tumor diagnostics and therapy were reviewed.