Analytical validation applied to simultaneous determination of solvents dichloromethane (DCM), methyl isobutyl ketone (MIBK), tetrahydrofuran (THF) and toluene (TOL) in urine by headspace extraction and injection on chromatographic system with a flame ionization detector

8th Brazilian Congress on Metrology

Muna, E.D.M.^1 ; Pereira, R.P.^1

Instituto Militar de Engenharia, IME, Praça Gen. Tibúrcio, 80, Urca - Rio de Janeiro

RJ, Brazil^1

关键词: Analytical procedure;    Analytical validation;    Chromatographic systems;    Flame ionization detectors;    Industrial activities;    Methyl isobutyl ketone;    Simultaneous determinations;    Volatile organic solvents;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/733/1/012013/pdf
DOI  :  10.1088/1742-6596/733/1/012013

来源: IOP

【 摘 要 】

The determination of the volatile organic solvents dichloromethane (DCM), methyl isobutyl ketone (MIBK), tetrahydrofuran (THF) and toluene (TOL) is applied on toxicological monitoring of employees in various industrial activities. The gas chromatography technique with flame ionization detector and headspace injection system has been applied. The analytical procedure developed allows the simultaneous determination of the above-mentioned solvents and the accuracy of the method was tested following the INMETRO guidelines through the DOQ-CGRE 008 Rev.04-July/2011.