Dosimetric impact of interplay effect in lung IMRT and VMAT treatment using in-house dynamic thorax phantom

13th South-East Asian Congress of Medical Physics 2015

物理学;医药卫生

Mukhlisin^1,2 ; Pawiro, S.A.^1

Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia^1

Nuclear Energy Regulatory Agency (BAPETEN), Jakarta, Indonesia^2

关键词: Dose delivery;    Dose reduction;    Dosimetric impact;    Dosimetry measurement;    Dosimetry verification;    Management techniques;    Radiotherapy treatment;    Thorax phantom;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/694/1/012009/pdf
DOI  :  10.1088/1742-6596/694/1/012009

学科分类：卫生学

来源: IOP

【 摘 要 】

Tumor motion due to patient's respiratory is a significant problem in radiotherapy treatment of lung cancer. The purpose of this project is to study the interplay effect through dosimetry verification between the calculated and delivered dose, as well as the dosimetric impact of leaf interplay with breathing-induced tumor motion in IMRT and VMAT treatment. In this study, a dynamic thorax phantom was designed and constructed for dosimetry measurement. The phantom had a linear sinusoidal tumor motion toward superior-inferior direction with variation of amplitudes and periods. TLD-100 LiF:Mg,Ti and Gafchromic EBT2 film were used to measure dose in the midpoint target and the spinal cord. The IMRT and VMAT treatment had prescription dose of 200 cGy per fraction. The dosimetric impact due to interplay effect during IMRT and VMAT treatment were resulted in the range of 0.5% to -6.6% and 0.9% to -5.3% of target dose reduction, respectively. Meanwhile, mean dose deviation of spinal cord in IMRT and VMAT treatment were around 1.0% to -6.9% and 0.9% to -6.3%, respectively. The results showed that if respiratory management technique were not implemented, the presence of lung tumor motion during dose delivery in IMRT and VMAT treatment causes dose discrepancies inside tumor volume.