Adsorption of vapreotide on gold colloids studied by surface enhanced Raman spectroscopy

3rd International Meeting for Researchers in Materials and Plasma Technology; 1st Symposium on Nanoscience and Nanotechnology

物理学;材料科学

Gómez, J.A.^1 ; Cabanzo, R.^1 ; Ospino, E. Mejia^1

Universidad Industrial de Santander, Bucaramanga, Colombia^1

关键词: Aromatic amino acid;    Gold colloid;    Optimum conditions;    Surface enhanced Raman spectroscopy;    Tryptophan residues;    Vibrational modes;    Wave numbers;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/687/1/012112/pdf
DOI  :  10.1088/1742-6596/687/1/012112

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Surface Enhanced Raman Spectroscopy (SERS) has been used to investigate the somatostatin (SST) analogue Vapreotide (VAP) in gold colloids. The optimum conditions to detect SERS signals of VAP have been studied. The observed SERS bands correspond to different vibrational modes of the peptide; being the most dominant SERS signals the ones derived from the aromatic amino acids Tryptophan (Trp), Phenylalanine (Phe) and Tyrosine (Tyr). Changes in enhancement and wavenumber of the proper bands upon adsorption on gold colloid are consistent with VAP adsorption, primarily through Tryptophan residues.