PROTEOTRONICS: The emerging science of protein-based electronic devices

19th International Conference on Electron Dynamics in Semiconductors, Optoelectronics and Nanostructures

Alfinito, Eleonora^1 ; Pousset, Jeremy^2 ; Reggiani, Lino^3

Dipartimento di Ingegneria dell'Innovazione, Universitá Del Salento, via Monteroni, Lecce

I-73100, Italy^1

Istituto per la Microelettronica e Microsistemi (IMM), Consiglio Nazionale Delle Ricerche, Lecce

I-73100, Italy^2

Dipartimento di Matematica e Fisica Ennio de Giorgi, Universitá Del Salento, via Monteroni, Lecce

I-73100, Italy^3

关键词: Biological process;    Electronic device;    Emerging science;    G protein coupled receptors;    Substance transport;    Theoretical modeling;    Trans-membrane proteins;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/647/1/012002/pdf
DOI  :  10.1088/1742-6596/647/1/012002

来源: IOP

【 摘 要 】

Protein-mediated charge transport is of relevant importance in the design of protein based electronics and in attaining an adequate level of understanding of protein functioning. This is particularly true for the case of transmembrane proteins, like those pertaining to the G protein coupled receptors (GPCRs). These proteins are involved in a broad range of biological processes like catalysis, substance transport, etc., thus being the target of a large number of clinically used drugs. This paper briefly reviews a variety of experiments devoted to investigate charge transport in proteins and present a unified theoretical model able to relate macroscopic experimental results with the conformations of the amino acids backbone of the single protein.