Applying robust control theory to solve problems in bio-medical sciences: study of an apoptotic model

2nd International Conference on Mathematical Modeling in Physical Sciences 2013

物理学;数学

Trujillo, M.^1 ; Becerra, V.M.^1 ; Hadjiloucas, S.^1

School of Systems Engineering, University of Reading, RG6 6AY, United Kingdom^1

关键词: Apoptotic;    Apoptotic process;    Bio-medical;    Biological models;    Biological process;    Dynamic uncertainty;    Naturally occurring;    System of differential equations;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/490/1/012140/pdf
DOI  :  10.1088/1742-6596/490/1/012140

来源: IOP

【 摘 要 】

Biological models of an apoptotic process are studied using models describing a system of differential equations derived from reaction kinetics information. The mathematical model is re-formulated in a state-space robust control theory framework where parametric and dynamic uncertainty can be modelled to account for variations naturally occurring in biological processes. We propose to handle the nonlinearities using neural networks.