Optical microrheology measurements for determination of sol-gel transitions of chitosan hydrogels

1st International Conference on Rheology and Modeling of Materials

物理学;材料科学

Domagalski, P.^1 ; Orczykowska, M.^1 ; Owczarz, P.^1 ; Dziubinski, M.^1

Faculty of Process and Environmental Engineering, Lodz Technical University, ul. Wolczanska 213, Lodz

93-005, Poland^1

关键词: Application of polymers;    Human body temperature;    Hydroxyethylcellulose;    Microrheology;    Poly(N-isopropylacrylamide);    Sol-gel phase transition;    Sol-gel transitions;    Thermo-sensitive hydrogel;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/602/1/012040/pdf
DOI  :  10.1088/1742-6596/602/1/012040

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

The combination of medicinal substance and an appropriate polymer matrix with specially adjusted permeability has became a basic form of medicine in the controlled drag delivery. One of main solutions used recently in pharmacology is the application of polymer matrices which form colloidal systems. The sol-gel phase transition is inhibited by a change of pH or temperature. Thermosensitive systems are produced from polymers whose sol-gel transition in water solutions depends on temperature. Thermosensitive hydrogel systems are currently obtained mainly from poly(N-isopropylacrylamide) (PNIPA), copolymer (polyethylene oxide - polypropylene oxide - polyethylene oxide), polyethylene glycol, lactic acid copolymer with glycolic acid and polyethylene glycol, and polysaccharides (xyloglucane, ethylcellulose, hydroxyethylcellulose and chitosan). At the temperature below 25°C these systems occur in the form of sols which at human body temperature are transformed into gels. Such systems belong to the so called intelligent ones and are a subject of special interest, particularly in view of their possible use as drug carriers and also as material for cell culture in the past.