Formation of intermolecular crosslinks by the actinocin derivatives with DNA in interaction under conditions of semidilute solution

16th Russian Youth Conference on Physics and Astronomy

物理学;天文学

Osinnikova, D.N.^1 ; Moroshkina, E.B.^1

St.Petersburg State University, St. Petersburg

199161, Russia^1

关键词: Actinocin derivatives;    Amino group;    Anomalous behavior;    Calf thymus DNA (ct-DNA);    Comparative studies;    Hydrodynamic behavior;    Macromolecular coils;    Semidilute solutions;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/572/1/012013/pdf
DOI  :  10.1088/1742-6596/572/1/012013

学科分类：天文学(综合)

来源: IOP

【 摘 要 】

Interaction of native calf thymus DNA (ctDNA) with the actinocin derivatives containing protonated diethylamino groups, dimethylamino groups and unsubstituted amino groups and having different length of the alkyl chain have been studied by the method of viscometry. An anomalous hydrodynamic behavior of solutions of DNA with very low amount of ligands prepared under conditions of semidilute solution was revealed. We assumed that such an anomalous behavior of solutions of DNA complexes with actinocin derivatives associated with the formation of intermolecular crosslinks while the preparation of the complex was in terms of overlapping of macromolecular coils in solution. Comparative study of the hydrodynamic behavior of the DNA complexes with various actinocin structures lead us to the conclusion of the formation of crosslinks by the compounds containing protonated diethylamino groups.