Modeling of the chemical stage in water radiolysis using Petri nets

2nd International Conference on Mathematical Modeling in Physical Sciences 2013

物理学;数学

Barilla, J.^1 ; Simr, P.^1 ; Lokajíek, M.^2 ; Pisaková, H.^2

J. E. Purkinje University in Usti Nad Labem, Faculty of Science, eské mládee 8, 400 96 Ústi nad Labem, Czech Republic^1

Institute of Physics, V.v.i., Academy of Sciences of the Czech Republic, Na Slovance 2, 182 21 Praha 8, Czech Republic^2

关键词: Biological effects;    Chemical substance;    Continuous Petri net;    Low-LET radiation;    Radical concentration;    Radiobiological effects;    Secondary particles;    Water radiolysis;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/490/1/012200/pdf
DOI  :  10.1088/1742-6596/490/1/012200

来源: IOP

【 摘 要 】

The biological effect of ionizing radiation is mediated practically always by the clusters of radicals formed by densely ionizing track ends of primary or secondary particles. In the case of low-LET radiation the direct effect may be practically neglected and the radical clusters meet a DNA molecule always some time after their formation. The corresponding damage effect (formation of DSB) depends then on the evolution running in individual clusters, being influenced by present chemical agents. Two main parallel processes influence then final effect: diffusion of corresponding radical clusters (lowering radical concentrations) and chemical reactions of all chemical substances present in the clusters. The processes running in the corresponding radical clusters will be modeled with the help of continuous Petri net, which enables us to study the concurrent influence of both the processes: lowering concentration of radicals due diffusion and due chemical reactions. The given model may be helpful especially when the effect of radicals on DSB formation (DNA damage) at the presence of different substances influencing radiobiological effect is to be studied.