Prospects for the use of animal cell cultures in screening of pharmaceutical substances

1st International Symposium 'Physics, Engineering and Technologies for Bio-Medicine'

医药卫生;物理学;工业技术

Kolesnikova, S.G.^1 ; Moiseeva, I.Y.^2

National Research Nuclear University, MEPhI (Moscow Engineering Physics Institute), Moscow

115409, Russia^1

Penza State University, Penza

440026, Russia^2

关键词: Chemical substance;    Compliance monitoring;    Drug testing;    In-vitro;    In-vivo;    International standards;    Laboratory practices;    Pre-clinical;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/784/1/012028/pdf
DOI  :  10.1088/1742-6596/784/1/012028

来源: IOP

【 摘 要 】

Currently, there is a tendency to reduce the use of animals in conducting safety tests of chemical substances. Therefore, in vitro methods are a good alternative or adjunct to in vivo safety tests. This is especially important at the stage of pre-clinical drug trial. In 2004, the international standard for the principles of good laboratory practice (GLP) [1] was adopted which regulates chemicals trials in cell cultures. However, in Russia, until recently, this issue has been neglected. Research works have been scarce. In 2013, the standard for GLP principles and compliance monitoring was adopted in Russia [2]. The feasibility of using animal cell cultures as drug testing system has been proved by the experimental base and is now being introduced into practice [3].