An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates

17th International Conference on the Use of Computers in Radiation Therapy

物理学;计算机科学

Carolan, Martin^1,2 ; Oborn, Brad^1,2 ; Foo, Kerwyn^3 ; Haworth, Annette^4 ; Gulliford, Sarah^5 ; Ebert, Martin^6,7

Illawarra Cancer Care Centre, Wollongong Hospital, Wollongong NSW 2500, Australia^1

Centre for Medical Radiation Physics, University of Wollongong, Wollongong NSW 2522, Australia^2

Department of Radiation Oncology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia^3

Peter McCallum Cancer Centre, Melbourne, Vic, Australia^4

Joint Department of Physics, Institute of Cancer Research, Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom^5

Sir Charles Gairdner Hospital, Nedlands, 6009, WA, Australia^6

School of Physics, University of Western Australia, Crawley, WA 6009, Australia^7

关键词: Clinical data;    Confidence interval;    Model parameters;    Toxicity endpoints;    Uncertainty estimates;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/489/1/012087/pdf
DOI  :  10.1088/1742-6596/489/1/012087

学科分类：计算机科学（综合）

来源: IOP

【 摘 要 】

The aims of this work were to establish a program to fit NTCP models to clinical data with multiple toxicity endpoints, to test the method using a realistic test dataset, to compare three methods for estimating confidence intervals for the fitted parameters and to characterise the speed and performance of the program.