Enhancement of radiation effects by bismuth oxide nanoparticles for kilovoltage x-ray beams: A dosimetric study using a novel multi-compartment 3D radiochromic dosimeter

7th International Conference on 3D Radiation Dosimetry

Alqathami, M.^1 ; Blencowe, A.^2 ; Yeo, U.J.^3 ; Franich, R.^3 ; Doran, S.^4,5 ; Qiao, G.^2 ; Geso, M.^1

School of Medical Sciences, RMIT University, VIC 3083, Australia^1

Department of Chemical and Biomolecular Engineering, University of Melbourne, VIC 3052, Australia^2

School of Applied Sciences, Health Innovations Research Institute, RMIT University, Melbourne, VIC 3001, Australia^3

Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom^4

CRUK, EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, United Kingdom^5

关键词: Bismuth oxides;    Clinical radiotherapy;    Dose enhancement factors;    Dose enhancements;    Experimental validations;    Optical CT;    X ray beam;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/444/1/012025/pdf
DOI  :  10.1088/1742-6596/444/1/012025

来源: IOP

【 摘 要 】

The aim of this study is to present the first experimental validation and quantification of the dose enhancement capability of bismuth oxide nanoparticles (Bi2O3-Nps). A recently introduced multi-compartment 3D radiochromic dosimeter for measuring radiation dose enhancement produced from the interaction of X-rays with metal nanoparticles was employed to investigate the 3D spatial distribution of ionizing radiation dose deposition. Dose-enhancement factor for the dosimeters doped with Bi2O3-NPs was ∼1.9 for both spectrophotometry and optical CT analyses. Our results suggest that bismuth-based nanomaterials are efficient dose enhancing agents and have great potential for application in clinical radiotherapy.