Phytocomponents and effect of aqueous extract of the leaves of Alstonia boonei (de wild) on serum electrolyte levels in wistar rats

8th International Biotechnology Conference, Exhibition and Workshop

Oshomoh, E.O.^1 ; Imoyera, J.^1

Department of Science Laboratory Technology, Faculty of Life Sciences, University of Benin, Benin City. Edo State, Nigeria^1

关键词: Aqueous extracts;    Female Wistar rats;    Metabolic products;    Phytochemicals;    Phytocomponents;    Renal functions;    Serum electrolyte;    Therapeutic agents;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/210/1/012016/pdf
DOI  :  10.1088/1755-1315/210/1/012016

来源: IOP

【 摘 要 】

Alstonia boonei, common name cheese wood contains major phytochemical compounds used for healing. This study evaluated the effects of the aqueous leaves extract of A.boonei on renal function of male and female wistar rats. Twenty-four (24) male and female wistar rats weighing between 120-230 g were randomly assigned into eight (8) groups (A - H) of three (3) rats per group. Groups (A and E) were used as male and female controls respectively while male groups (B - D) and female groups (F - H) served as the test groups and received 500, 1000 and 2500 mg/kg of the extract respectively. After twenty-eight days of extract administration all the animals were fasted for twenty-four hours and sacrificed. Blood was collected by cardiac puncture for analysis of serum electrolytes. The results revealed insignificant difference (P > 0.05) in the serum levels for males and females at the doses tested except level of urea in female rats, it also revealed significant (P