The Preparation of ZnO@Chitosan@Gelatin Composite Nanofibers for Tissue Engineering Applications

2018 International Conference on Civil and Hydraulic Engineering

土木建筑工程;水利工程

Liu, Le-Yun^1 ; Chen, Peng^1 ; Pan, Jia-Qi^1 ; Zheng, Ying-Ying^1

Department of Physics, Key Laboratory of ATMMT Ministry of Education Zhejiang, Sci-Tech University, Hangzhou

310018, China^1

关键词: Chitosan gelatins;    Coaxial electrospinning;    Composite scaffolds;    Cytocompatibility;    Polyethylene oxide (PEO);    rf-Magnetron sputtering;    Three-dimensional networks;    Tissue engineering applications;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/189/3/032041/pdf
DOI  :  10.1088/1755-1315/189/3/032041

学科分类：土木及结构工程学

来源: IOP

【 摘 要 】

Chitosan is a novel biocompatible, biodegradable polymer for potential use in tissue engineering. In this work, ZnO@chitosan (CS)@gelatin (GEL) composite scaffolds were prepared by combining coaxial electrospinning methods and RF magnetron sputtering. And polyethylene oxide (PEO) was added into CS solution to improve spinnability. The prepared CS-PEO@GEL nanofibers were characterized using SEM and TEM. The prepared ZnO@CS-PEO@GEL composite scaffolds were characterized using SEM, XRD and LSCM studies. The composite scaffolds were three-dimensional network structured. In addition, cytotoxicity of the composite scaffolds were studied by CCK-8 assay. The scaffolds showed good biocompatibility and cytocompatibility, according to this study.