Antihyperglycemic and antihyperlipidemic effects of pirdot (saurauia vulcani korth.) leaves extract in mice

3rd International Conference on Biological Sciences and Biotechnology

Hutahaean, Salomo^1 ; Tanjung, Masitta^1 ; Sari, Diah Puspita^1 ; Ningsih, Vevy Elfia^1

Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Kampus USU, Jl. Bioteknologi No. 1, Medan

20155, Indonesia^1

关键词: Anti-Diabetic Drugs;    Blood glucose level;    Control groups;    Diabetic patient;    Hyperlipidemia;    Saurauia vulcani;    Total cholesterols;    tryglyceride;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/130/1/012042/pdf
DOI  :  10.1088/1755-1315/130/1/012042

来源: IOP

【 摘 要 】

Approximately eighty percent of deaths in diabetic patients result from atherosclerosis, which is related to hyperlipidemia tendencies in diabetes. In North Sumatra, the use of plant-based ingredients as diabetes therapy has long been recognized. One of the local species which traditionally used was the pirdot plant (Saurauia vulcani Korth.). In this paper, we report the antihyperglycemic and antihyperlipidemic effects of the extract of pirdot leaves in model mice. In experiment I, twenty - five alloxan-induced diabetic mice was divided randomly into five groups of 5 mice, namely: control diabetic mice; diabetic mice + metformin; and three groups diabetic mice + pirdot leaves extract of 100, 200, or 300 mg/kg BW respectively. All the treatments were given daily for 21 days by oral gavage. In experiment II, another twenty-five mice were divided randomly into five groups of 5 mice. The treatments were as follows: a control group that did not receive any treatment; hyperlipidemic control (received quail yolk diet) for 30 days; and three groups of hyperlipidemic mice + orally treated pirdot leaves extract at a dose of 100, 200, or 300 mg/kg BW respectively. The result showed the pirdot leaves extract has the potential as antihyperglycemic. The effects obtained are equivalent to the effects of antidiabetic drug metformin. On the other hand, the antihyperlipidemic effect was not conclusive, because the extract lowered total cholesterol significantly, but no significant effect on triglyceride, marked reduced LDL, but significantly decreased the HDL level.