A bibliometric analysis of research updates and tendencies on steroid biotransformation

3rd International Conference on Energy Equipment Science and Engineering

Song, Zhaoyu^1

Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin

300457, China^1

关键词: Active pharmaceutical ingredients;    Bibliometric analysis;    China and India;    Cytochrome p450;    Developing nations;    Research outputs;    Science citation index;    Side chain oxidation;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/128/1/012132/pdf
DOI  :  10.1088/1755-1315/128/1/012132

来源: IOP

【 摘 要 】

Steroid biotransformation, as a powerful tool for generation of steroid active pharmaceutical ingredients and key intermediates, has received widespread attention with increasing market demand for steroid-based drugs. In our study, a bibliometric analysis of steroid biotransformation was performed to trace the research updates and tendencies from 1993 to 2016, based on the Science Citation Index Expanded (SCIE) database. Results showed a notable growth trend in publication outputs. Although the USA was the most productive country between 1993 and 2016, developing nations, including China and India, contributed the prominent growth in recent years (2005-2016). Steroids was the leading journal in this field, and the research outputs had notably increased in the field of 'Chemistry', 'Pharmacology and Pharmacy' and 'Biotechnology and Applied Microbiology'. Finally, research focused mainly on the efficient production of novel steroid active pharmaceutical ingredients and key intermediates through steroid biotransformation. Furthermore, cytochrome P450 involved in the side-chain oxidation of sterols has gradually become a hotspot issue in recent years.