Difference of protein 53 expression based on radiation therapy response in cervical cancer

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Pasaribu, H.P.^1 ; Lubis, L.I.^1 ; Dina, S.^1 ; Simanjuntak, R.Y.^1 ; Siregar, H.S.^1 ; Rivany, R.^1

Department of Obstetrics and Gynecology, Haji Adam Malik General Hospital, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

关键词: Cancer patients;    Cervical cancers;    Complete response;    Confidence interval;    Control samples;    General hospitals;    Radiation response;    Study samples;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012190/pdf
DOI  :  10.1088/1755-1315/125/1/012190

来源: IOP

【 摘 要 】

Cervical cancer is one of most common gynecological cancer in women and the leading cause of death in developing countries. An analytic study with the case-control design was conducted to determine the difference of p53 expression based on radiation therapy response in cervical cancer. The study was performed in Obstetric and Gynecology Department and Pathology Department of Adam Malik General Hospital Medan from January to February 2017. 15 paraffin blocks of acervical cancer patient with incomplete response were obtained as study samples, and 15 paraffin blocks of acervical cancer patient with complete response were obtained as control samples, The samples were collected by consecutive sampling, andan immunohistochemical assessment of p53 expression was done to assessapoptosis count and radiation response. Data were analyzed using Kruskal-Wallis with confidence interval 83.5% and p