Complete response of sunitinib therapy for renal cell cancer recurrence in the native kidney after renal transplantation: a case report

BMC Research Notes

Tsuneharu Miki¹  Koji Okihara¹  Kazumi Kamoi¹  Yoshio Naya¹  Terukazu Nakamura¹  Yasuyuki Naitoh¹  Takashi Ueda¹  Masakatsu Oishi¹  Fumiya Hongo¹ 

[1] Department of Urology, Kyoto Prefectural University of Medicine, 465 Kajii-cho Kamigyo-ku, Kyoto 602-8566, Japan

关键词: Tumor thrombus;    Sunitinib;    Renal transplantation;    Renal cell cancer;    Presurgical therapy;    Neoadjuvant therapy;    Native kidney;    Complete response;   

Others  :  1130497
DOI  :  10.1186/1756-0500-7-526

 received in 2014-03-04, accepted in 2014-08-08,  发布年份 2014

【 摘 要 】

Background

No case report has yet shown that sunitinib therapy for the postoperative recurrence of renal cancer in a native kidney after renal transplantation can achieve complete response (CR).

Case presentation

A tumor was detected in the right native kidney of a 35-year-old Japanese male 10 years after renal transplantation. A tumor thrombus that reached the atrium was detected, which suggested cT3cN0M0. Because of the risk of perioperative complications, preoperative therapy with sunitinib was selected and 8 courses were administered. The size of the primary tumor was reduced by 33%, while that of the tumor thrombus was decreased by 39.5%.

Right nephrectomy and removal of the tumor thrombus were then performed. Contrast-enhanced computed tomography (CT) four months after surgery suggested local relapse. Sunitinib was administered for 9 months, which led to complete response (CR).

Conclusions

This study presented the case of sunitinib therapy for renal cancer in the native kidney after renal transplantation. The therapeutic efficacy and safety for such cases should be discussed.

【 授权许可】

   
2014 Hongo et al.; licensee BioMed Central Ltd.

【 图 表 】

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