1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara | |
Vitamin C supplementation improve the sputum conversion culture rate in pulmonary tuberculosis treatment while rifampicin susceptible | |
Susanto, L.^1 ; Siregar, Y.^1 ; Kusumawati, L.^2 | |
Biomedical Science Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1 | |
Multi-Drug Resistent TB Laboratory, Haji Adam Malik General Hospital, Medan, Indonesia^2 | |
关键词: Conversion rates; Healing process; M. tuberculosis; Parallel design; Plasma levels; Post treatment; Pulmonary tuberculosis; Tuberculosis patients; | |
Others : https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012140/pdf DOI : 10.1088/1755-1315/125/1/012140 |
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来源: IOP | |
【 摘 要 】
The failure of first-line tuberculosis treatment greatly affects multiple drug-resistant tuberculosis. In vitro study of vitamin C induces the death of M. tuberculosis bacteria and accelerates healing of tuberculosis, so the multiple drug-resistant tuberculosis can be avoided. This research aimed to identify the effect of vitamin C as a supportive treatment on the sputum conversion rate. The randomizedand double group with a parallel design by matching pair method was used to collect samples. The first group was treated with standard tuberculosis treatment, and the other was given vitamin C supplementation. Vitamin C plasma level analyzation was performed before and after two months of treatment. Sputum conversion was evaluated every week for eight weeks. The comparison of vitamin C plasma level in pre and post-treatment group was significant (p=0.03) but not in the other group. There was no significant difference in vitamin C plasma level between two groups (p=0.21). The proportion of sputum conversion rate in both group in the first week was 0% vs. 9.6% (p=0.83) and the last week of study was 83.9% vs. 100% (p=0.02). In conclusion, vitamin C supplementation has effects in improving the healing process of tuberculosis patients as indicated by higher in sputum conversion rate.
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Vitamin C supplementation improve the sputum conversion culture rate in pulmonary tuberculosis treatment while rifampicin susceptible | 215KB | download |