Vitamin C supplementation improve the sputum conversion culture rate in pulmonary tuberculosis treatment while rifampicin susceptible

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Susanto, L.^1 ; Siregar, Y.^1 ; Kusumawati, L.^2

Biomedical Science Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

Multi-Drug Resistent TB Laboratory, Haji Adam Malik General Hospital, Medan, Indonesia^2

关键词: Conversion rates;    Healing process;    M. tuberculosis;    Parallel design;    Plasma levels;    Post treatment;    Pulmonary tuberculosis;    Tuberculosis patients;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012140/pdf
DOI  :  10.1088/1755-1315/125/1/012140

来源: IOP

【 摘 要 】

The failure of first-line tuberculosis treatment greatly affects multiple drug-resistant tuberculosis. In vitro study of vitamin C induces the death of M. tuberculosis bacteria and accelerates healing of tuberculosis, so the multiple drug-resistant tuberculosis can be avoided. This research aimed to identify the effect of vitamin C as a supportive treatment on the sputum conversion rate. The randomizedand double group with a parallel design by matching pair method was used to collect samples. The first group was treated with standard tuberculosis treatment, and the other was given vitamin C supplementation. Vitamin C plasma level analyzation was performed before and after two months of treatment. Sputum conversion was evaluated every week for eight weeks. The comparison of vitamin C plasma level in pre and post-treatment group was significant (p=0.03) but not in the other group. There was no significant difference in vitamin C plasma level between two groups (p=0.21). The proportion of sputum conversion rate in both group in the first week was 0% vs. 9.6% (p=0.83) and the last week of study was 83.9% vs. 100% (p=0.02). In conclusion, vitamin C supplementation has effects in improving the healing process of tuberculosis patients as indicated by higher in sputum conversion rate.