Acute and subacute toxicities effect of oxytetracycline pharmaceutical wastewater on Zebrafish

3rd International Conference on Advances in Energy Resources and Environment Engineering

能源学;生态环境科学

Wu, Pengpeng^1 ; Shen, Hong-Yan^1

College of Environmental Science and Engineering, Pharmaceutical Molecular Chemistry Laboratory of Hebei Province, Hebei University of Science and Technology, Shijiazhuang, China^1

关键词: Exposure groups;    Muscle tissues;    Oxytetracyclines (OTC);    Pharmaceutical wastewater;    SOD activities;    Superoxide dismutase activities;    Treatment group;    Volume concentration;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/113/1/012142/pdf
DOI  :  10.1088/1755-1315/113/1/012142

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

Oxytetracycline wastewater is a major category of pharmaceutical wastewater, and its toxic effects on aquatic organisms have aroused people's attention. In this study, Zebrafish were separately exposed to four Oxytetracycline wastewater treatments (20%, 40%, 60%, 80%) and a control group were sampled on days 3, 6, 9, 12, and 15. Superoxide dismutase (SOD) activities showed significant inhibition, but the highest SOD activity was found in 20% and 40% the treatment groups (195.12U/mgprot, 187.43U/mgprot, respectively) on the 12th day. MDA contents increased significantly compared with control group. MDA contents showed that the higher the volume concentration, the higher the contents of MDA with the increase of exposure time. The highest MDA content shown in 60% exposure group (5.49nmol/mgprot) on the 12th day. And SOD activities and MDA contents showed a trend of "Λ" type. In conclusion, Oxytetracycline wastewater induced oxidative stress and toxicity in Zebrafish muscle tissue.