Evaluate the Influence of Eupatorium adenophorum Extract with Mice Organ

2017 3rd International Conference on Environmental Science and Material Application

生态环境科学;材料科学

Nong, Xiang^1,2 ; Yang, Can^1,2 ; Yang, Yaojun^1,2 ; Liang, Zi^1,2 ; Hu, Qiang^1,2 ; Zhang, Ting^1,2

Bamboo Diseases and Pests Control and Resources Development Key Laboratory of Sichuan Province, Leshan Normal University, Leshan Sichan

614000, China^1

College of Life Sciences, Leshan Normal University, Leshan Sichan

614000, China^2

关键词: Blank control group;    Cell morphology;    In-depth study;    Individual cells;    Levonorgestrel;    Male mouse;    Tissue sections;    Treatment group;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/108/2/022036/pdf
DOI  :  10.1088/1755-1315/108/2/022036

来源: IOP

【 摘 要 】

In order to study the influence of extract from Eupatorium adenophorum in mice organs, this experiment will be the basis of further study that make Eupatorium adenophorum become Phyto contraceptive, this experiment take the feeding respectively way after the completion of the 1D, 5D, 10d, 15d of Eupatorium adenophorum mice by intragastrical administration of levonorgestrel group and blank control group. After the same operation in different periods of small rat heart and kidney the uterus, testis, and other organs were observed. The results showed that after extraction of E. adenophorum changes in female mice uterus shape was perfused significantly, showed swelling larger. Data analysis of each viscera coefficient was found E. adenophorum had No obvious effect on the heart, kidneys and testicles of mice. but there are obvious differences date between the treatment group and the blank group. (5d: F=10. 800 P=0. 043 cases) from tissue sections we can see female mice uterus cell morphology changes significantly, there was a similar appearance change in the uterus of the female mice with the estradiol For a male mouse testis of E.adenophorum gavage had No obvious effect. And it is found that the heart, the treated mice kidney, testis, ovary and other organs were observed in each period of time the organization had No obvious change; only female mice uterus tissue sections of individual cells became larger, and the organization of the gap larger. This research shows that E.adenophorum extract has the potential to develop botanical contraceptives, we will conduct in-depth study.