In Silico Studies in Antimicrobial Peptides Design and Development

4th International Conference on Biological Sciences and Biotechnology

Rinanda, T.^1

Department of Microbiology, Faculty of Medicine, Syiah Kuala University, Jalan Tanoh Abee, Darussalam, Banda Aceh

23115, Indonesia^1

关键词: Anti-microbial activity;    Antimicrobial peptide;    Broad spectrum;    Cost effective;    Design and Development;    Immunomodulatory;    In-silico;    Mode of action;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/305/1/012062/pdf
DOI  :  10.1088/1755-1315/305/1/012062

来源: IOP

【 摘 要 】

Antimicrobial peptides (AMPs) are a group of natural-derived molecules exhibited broad spectrum antimicrobial activity. Currently these molecules have been investigated comprehensively due to their interesting features regarding antimicrobial and immunomodulatory mode of actions which placed them as promising therapeutics agents in this post antibiotics era. Numerous strategies have been implemented in order to develop a novel AMP for biotechnology and therapeutics applications, one of which is in silico study.. This approach offers a rapid and cost effective manner in AMPs design and development. In silico studies provide additional and substantial information for in vitro techniques. In this paper, we deliver an overview of the applicable in silico approaches that have been used in designing and developing AMPs.