In vivo sub chronic toxicity evaluation of the methanol extract of Meretrix meretrix Linnaeus in Sprague dawley rats

3rd EMBRIO International Workshop on Marine Biodiversity: Understanding, Utilization, Conservation

生态环境科学

Apriandi, A.^1 ; Tarman, K.^2 ; Sugita, P.^3

Fisheries Product Biotechnology Laboratory, Raja Ali Haji Maritime University, Indonesia^1

Aquatic Product Technology of Department, Bogor Agricultural University, Bogor, Indonesia^2

Chemistry of Department, Bogor Agricultural University, Indonesia^3

关键词: Blood chemistry;    Blood serum;    Chronic toxicity;    Diagnostic tests;    Meretrix meretrix linnaeus;    Methanol extract;    Normal condition;    Sprague-Dawley rats;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/278/1/012006/pdf
DOI  :  10.1088/1755-1315/278/1/012006

学科分类：环境科学（综合）

来源: IOP

【 摘 要 】

This study aims to determine the effect of the methanol extract of sea water clams (Meretrix meretrix) against blood chemistry profile in vivo in Sprague Dawley rats. After three months fed by two different methanol extract concentration i.e. 0.1 g. kg-1 body weight (M/0.1) and 1 g. kg-1 body weight (M/1), blood serum has been taken prior for the analysis using Biocon Diagnostic test kit quantitatively. Based on the observations, growth, feed intake, weight of liver and kidney were found in normal conditions. When comparing urea, creatinine and cholesterol extents among the control and treated mices were not significantly different (p>0.05) while the levels of bilirubin and albumin between control rats treated with M/0.1 and M/1 results in different significantly (p