Optimization of Supercritical CO2 Fluid Extraction of Flavonoids from Spina Gleditsiae by Response Surface Method

4th International Conference on Energy Equipment Science and Engineering

Liu, Xiaojuan^1 ; Gao, Xia^1

Jiangsu Provincial Xuzhou Pharmaceutical Vocational College, Xuzhou, China^1

关键词: Extraction pressure;    Extraction process;    Extraction temperatures;    Fluid extraction;    Response surface method;    Response surface methodology;    Single-factor experiments;    Supercritical CO2;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/242/4/042015/pdf
DOI  :  10.1088/1755-1315/242/4/042015

来源: IOP

【 摘 要 】

In order to optimize the supercritical CO2 fluid extraction of flavonoids from spina gleditsiae, single-factor experiments were utilized to investigate the influences of the extraction temperature, extraction pressure, and entrainment dosage firstly. Then the optimal extraction process for flavonoids extraction was determined by response surface methodology and the quadratic mathematical model was established which reliability was finally verified. The optimal supercritical CO2 fluid extraction conditions were as follows: entrainment dosage of 36mL, extraction temperature of 48°Cand extraction pressure of 40Mpa. Under this condition, the yield of flavonoids from spina gleditsiae was 0.793%.