Solubility characteristics of the material based on porous hydroxyapatite ceramics coated with PLGA

16th International Conference of Students and Young Scientists "Prospects of Fundamental Sciences Development"

自然科学（总论）

Lytkina, D.^1 ; Gutsalova, A.^1 ; Pozdniakov, M.^1 ; Heinrich, L.^1^2 ; Kozik, V.^1

National Research Tomsk State University, Russia^1

University of Muenster, Germany^2

关键词: Dissolution rates;    Material-based;    Pore-forming agents;    Porous hydroxyapatite;    Porous hydroxyapatite ceramics;    SEM image;    Solubility characteristics;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/597/1/012006/pdf
DOI  :  10.1088/1757-899X/597/1/012006

学科分类：自然科学（综合）

来源: IOP

【 摘 要 】

Composites based on a porous hydroxyapatite carcass with a coating of PLGA were obtained. According to the SEM images, it was found that, the composites had a different coating character depending on the porosity of the HA framework. After 1 week, the dissolution rate of composites increases relative to pure PLGA, and the growth is proportional to the increasing of the amount of pore-forming agent in the material by 20-50%. The dissolution rate of HA in the composition of materials also increases since the second week, because the diffusion of the solvent in the HA increases as the result of PLGA hydrolysis.