Preparation of Nanocellulose-Alginate Nanocomposites for Chlorhexidine Digluconate Drug Carrier

International Conference on Design and Application of Engineering Materials in conjunction with Seminar Nasional Metalurgi dan Material XI (SENAMM)

材料科学;金属学

Evelyna, Angela^1 ; Astifanni, Tiara Khumaira^1 ; Ruth, Imelda^1 ; Asri, Lia^2 ; Purwasasmita, Bambang Sunendar^3^4

Faculty of Dentistry, Maranatha Christian University, Indonesia^1

Materials Science and Engineering, Bandung Institute of Technology, Indonesia^2

Advanced Materials Processing Group, Engineering Physics Study Program, Bandung Institute of Technology, Indonesia^3

Research Center for Nanosciences and Nanotechnology, Bandung Institute of Technology, Indonesia^4

关键词: Average diameter;    Chlorhexidine digluconate;    Dentinal tubules;    Microcapsules;    Palm kernel cake;    Root canal treatment;    Scanning electron microscopy image;    Transmission electron microscopy images;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/547/1/012046/pdf
DOI  :  10.1088/1757-899X/547/1/012046

学科分类：材料科学（综合）

来源: IOP

【 摘 要 】

Root canal treatment failures generally caused by microorganisms that have ability to invade dentinal tubules. Chlorhexidine is widely known to effectively eradicate broad spectrum bacteria that infected dentinal tubules. The delivery of chlorhexidine to the infected site of root canal still becomes an issue. In order to increase the stability and to regulate the release of chlorhexidine, encapsulation of chlorhexidine digluconate was conducted by employing nanocellulose and alginate nanocomposites. Nanocellulose was prepared from palm kernel cake using acid hydrolysis method. Transmission electron microscopy images showed the formation of whisker and fiber nanocellulose with the average diameter of 20 nm. Resulting nanocellulose was combined with alginate in the presence of Ca2+ crosslinker. Scanning electron microscopy images displayed sphere and oval morphologies of microcapsules with diameter of 500 nm. The microcapsules were further loaded with chlorhexidine digluconate 2% (w/v). In vitro drug release properties were evaluated in PBS at pH 7.4 (normal tooth environment) and at pH 5.5 (infected tooth environment). The UV-VIS results showed that chlorhexidine digluconate has higher release rate at pH 5.5 than at pH 7.4, suggesting that the microcapsule is a good candidate for the delivery of chlorhexidine digluconate to the infected root canal tooth environment.