Comparison of DNA damage level in irradiated blood cells of mouse, frog and human

2nd International (15th Regional) Scientific Conference "Technogenic Systems and Environmental Risk"

工业技术（总论）;生态环境科学

Mitroshina, I.Y.^1 ; Sirota, N.P.^1 ; Kuznetsova, E.A.^1

Institute of Theoretical and Experimental Biophysics of the Russian Academy of Science, Moscow Region, Institutskaya st. 3, Pushchino

142290, Russia^1

关键词: Additional experiments;    Blood cells;    Comparative studies;    DNA repair process;    Environmental radiation;    Human blood cells;    Internal exposure;    X ray irradiation;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/487/1/012016/pdf
DOI  :  10.1088/1757-899X/487/1/012016

来源: IOP

【 摘 要 】

Here, we present the comparative studies of DNA damage induced by X-ray irradiation in vitro in mouse, frog and human blood cells and assessed by the "comet test" (alkaline version). We showed that, in contrast to mouse and human cells, DNA repair processes in frog blood cells are not completed by 60 minutes of the post-radiation period. The results suggest that frogs can be used as indicators of environmental radiation pollution. In this regard, additional experiments are needed to assess the different types of external and internal exposure of animals.