• 已选条件：
  • × Hao Liu
  • × 期刊论文
  • × 急救医学
 全选  【符合条件的数据共：2条】

1 An updated analysis of opioids increasing the risk of fractures [期刊论文]

PLoS One,2020年

Qiaoning Yue, Yue Ma, Yirong Teng, Yun Zhu, Hao Liu, Shuanglan Xu, Jie Liu, Jianping Liu, Xiguang Zhang, Zhaowei Teng

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Objective To assess the relationship between opioid therapy for chronic noncancer pain and fracture risk by a meta-analysis of cohort studies and case-control studies.

    2 The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis [期刊论文]

    PLoS One,2019年

    Carl L. Manthey, Beverley A. Moore, Yanqing Chen, Matthew J. Loza, Xiang Yao, Hao Liu, Stanley M. Belkowski, Holly Raymond-Parks, Paul J. Dunford, Francisco Leon, Jennifer E. Towne, Scott E. Plevy

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    Background & aims Originally believed to be primarily a disorder of T-cell signaling, evidence shows that macrophage-lineage cells also contribute to the pathogenesis of Crohn’s disease (CD). Colony stimulating factor-1 (CSF-1) is a key regulator of the macrophage lineage, but its role in CD has not been well established. We examined transcriptional data from CD mucosa for evidence of CSF-1 pathway activation and tested JNJ-40346527 (PRV-6527), a small molecule inhibitor of CSF-1 receptor kinase (CSF-1R), for its ability to inhibit disease indices in murine colitis.