This study examined the association between suicidal ideation and posttraumatic stress disorder (PTSD) symptom trajectories in a nationally representative sample of United States Reserve Component soldiers. PTSD symptoms related to a traumatic event during the most recent deployment were assessed in four annual waves in 2010-2013 among 682 Reserve Component soldiers. Latent Growth Mixture Modeling (LGMM) was used to examine the longitudinal trajectories of PTSD symptoms. The association between the PTSD trajectories and suicidal ideation at waves 2 to 4 was examined in logistic regression analyses. Four trajectories were identified: resilience (73.0%), recovery (11.7%), late onset (11.6%) and chronic (3.6%). Pairwise comparisons demonstrated significant differences between trajectories in risk of suicidal ideation. Among the chronic trajectory group, 50.9% reported suicidal ideation (25.8% late onset group; 11.3% recovery group; 4.0% resilience group). After controlling for baseline characteristics, the late onset and chronic trajectory groups were more likely to have suicidal ideation than the resilience and recovery trajectories, respectively. Findings suggest the late onset and chronic trajectories of PTSD symptoms are associated with higher risk of suicidal ideation. They support the importance of follow-up assessment of suicide risk even among individuals with low PTSD symptoms at homecoming.

Immunoglobulin E (IgE) has been suggested as a risk factor for allergy-induced low blood pressure, which has not been well explained in molecular details. Our current study shows a novel mechanism involving IgE, Fc epsilon R1, miRNA-212-5p (miR-212-5p), and sodium/calcium exchanger protein 1(NCX1) for asthma to induce hypotension. In arterial smooth muscle cells, IgE up-regulated miR212-5p via its receptor FceR1, which resulted in down regulation of NCX1 that is a regulating factor for blood pressure. In mice, asthma induced hypotension by interfering vasoconstrictive function; knockout of FceR1 kept the asthmatic mice from developing hypotension; knock-down of miR-212-5p in asthmatic mice resulted in a significant restoration of blood pressure. In human, asthma and IgE were positively correlated with hypotension in cohort study on NIH epidemiological data. This study suggests a novel therapeutic target (miR-212-5p) for treatment of asthma-induced hypotension.

Here we demonstrate a facile synthesis of nanoparticle-assembled mesoporous ZnO sheets by calcination of a novel sheet-like delta-Zn(OH)(2) precursor at low temperature (100 degrees C). The mesoporous ZnO sheets were assembled by ultrasmall ZnO nanoparticles with an average crystal size less than 10 nm, having a high specific surface area of 87.63 m(2) g(-1). The high specific surface area, rich mesopores and oxygen vacancies, and the small crystal size of the ZnO nanoparticles contributed to the good NO2 sensing performance of the sensors. The comparison study indicated that the mesoporous ZnO sheets assembled by the smallest nanoparticles exhibited the highest response to ppm level of NO2 at room temperature (the response to 1 ppm of NO2 was 135%). Moreover, the sensor exhibited high response/recovery rates, full reversibility and good selectivity to NO2. Based on the surface depletion model, the higher response of the mesoporous ZnO sheets assembled by the smaller nanoparticles was attributed to their more significant narrowing of the conduction channel upon exposure to NO2. (C) 2018 Published by Elsevier B.V.

L-2-Amino-4-phosphonobutyric acid (L-AP4) is a known potent and selective agonist for the Group III mGlu receptors. However, it does not show any selectivity among the individual group III mGlu subtypes. In order to understand the molecular basis for this group selectivity, we solved the first human mGlu8 amino terminal domain (ATD) crystal structures in complex with L-glu and L-AP4. In comparison with other published L-glu-bound mGlu ATD structures, we have observed L-glu binds in a significantly different manner in mGlu1. Furthermore, these new structures provided evidence that both the electronic and steric nature of the distal phosphate of L-AP4 contribute to its exquisite Group III functional agonist potency and selectivity. (C) 2018 Elsevier Ltd. All rights reserved.

Core-shell Fe3O4@Fe ultrafine nanoparticles (nano-Fe3O4@Fe, Fe3O4 content 84 wt%) with a core (Fe) diameter of 5.1 +/- 1.4 nm and a shell (Fe3O4) diameter of 10.9 +/- 1.6 nm is prepared by a liquid-phase pyrolysis and partial oxidation method. It is found that the core-shell Fe3O4@Fe ultrafine nanostructure can efficiently improve the electrochemical performance of Fe3O4 as anode material for Li-ion batteries in terms of rate capability and cycle life. For instance, specific capacities of 884 and 705 mAh/g can be obtained for the nano-Fe3O4@Fe electrode after 100 cycles at 200 mA/g and 500 cycles at 1000 mA/g, respectively. It is believed that these improvements can be attributed to the significant shortened transfer distance of electrons and Li-ions with relatively low specific surface area, ultrahigh electronic conductivity inside the nanoparticles and good ductility to accommodate the asymmetric volume change. (C) 2017 Elsevier B.V. All rights reserved.

Here we report the near infrared light (NIR) activated room-temperature NO2 gas sensors based on ZnO/PbS nanocomposites. The nanocomposites were composed of PbS quantum dots (QDs)-decorated ZnO nanorods with an urchin-like hierarchical mesoporous structure. The nanocomposites showed NIR adsorption derived from the PbS QDs with a narrow band gap. Compared to the pristine ZnO nanorods, the ZnO/PbS nanocomposites-based sensor with the optimal loading amount of PbS exhibited higher response and quicker response/recovery rates to parts per million (ppm) level of NO2 at room temperature under NIR illumination. Moreover, the sensor exhibited full reversibility, low detection limit, good selectivity and long-term stability to NO2. Photoluminescence and I-V characterization revealed the electron transfer from the excited PbS QDs to ZnO nanorods under NIR illumination, which enhanced the radial modulation of the conduction channel of ZnO nanorods, leading to the improved NO2 sensing performances of the ZnO/PbS nanocomposites at room temperature. (C) 2017 Published by Elsevier B.V.