Collaborative Research: Molecular Programming Architectures, Abstractions, Algorithms, and Applications,,A7942015年
Yang, Yang, Wang, Jing, Shigematsu, Hideki, Xu, Weiming, Shih, William M, Rothman, James E, Lin, Chenxiang.
LicenseType:Others | 英文
Collaborative Research: Molecular Programming Architectures, Abstractions, Algorithms, and Applications,,A7892015年
Yang, Yang, Wang, Jing, Shigematsu, Hideki, Xu, Weiming, Shih, William M, Rothman, James E, Lin, Chenxiang.
LicenseType:Others | 英文
PUBLIC HEALTH NUTRITION,,182015年
Vogtmann, Emily, Yang, Gong, Li, Hong-Lan, Wang, Jing, Han, Li-Hua, Wu, Qi-Jun, Xie, Li, Cai, Quiyin, Li, Guo-Liang, Waterbor, John W., Levitan, Emily B., Zhang, Bin, Gao, Yu-Tang, Zheng, Wei, Xiang, Yong-Bing, Shu, Xiao-Ou
英文
JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR,,472015年
Wang, Jing, Ye, Lei, Zheng, Yaguang, Burke, Lora E.
英文
FOOD CHEMISTRY,,1752015年
Wang, Lei, Jin, Peng, Wang, Jing, Jiang, Lulu, Shan, Timin, Zheng, Yonghua
英文
NEUROBIOLOGY OF AGING,,362015年
Chauhan, Ganesh, Adams, Hieab H. H., Bis, Joshua C., Weinstein, Galit, Yu, Lei, Toglhofer, Anna Maria, Smith, Albert Vernon, van der Lee, Sven J., Gottesmanm, Rebecca F., Thomson, Russell, Wang, Jing, Yang, Qiong, Niessen, Wiro J., Lopez, Oscar L., Becker, James T., Phan, Thanh G., Beare, Richard J., Arfanakis, Konstantinos, Fleischman, Debra, Vernooij, Meike W., Mazoyer, Bernard, Schmidt, Helena, Srikanth, Velandai, Knopman, David S., Jack, Clifford R., Jr., Amouyel, Philippe, Hofman, Albert, DeCarli, Charles, Tzourio, Christophe, van Duijnc, Cornelia M., Bennett, David A., Schmidt, Reinhold, Longstreth, William T., Jr., Mosley, Thomas H., Fornage, Myriam, Launer, Lenore J., Seshadri, Sudha, Ikramc, M. Arfan, Debette, Stephanie
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Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume, total brain volume, hippocampal volume (HV), white matter hyperintensity burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N = 8175-11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (p = 0.0054) and CD33 (rs3865444) with smaller intracranial volume (p = 0.0058). In gene-based tests, there was associations of HLA-DRB1 with total brain volume (p = 0.0006) and BIN1 with HV (p = 0.00089). A weighted AD genetic risk score was associated with smaller HV (beta +/- SE = -0.047 +/- 0.013, p = 0.00041), even after excluding the APOE locus (p = 0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in nondemented older community persons. (C) 2015 Elsevier Inc. All rights reserved.