Ethnomedicinal value of Pterocarpus santalinus (Linn. f.), a Fabaceae member Review First Online: 02 October 2014 Received: 27 January 2014 Accepted: 15 September 2014 DOI :
10.1007/s13596-014-0168-0
Cite this article as: Navada, K.K. & Vittal, R.R. Orient Pharm Exp Med (2014) 14: 313. doi:10.1007/s13596-014-0168-0
Abstract Pterocarpus santalinus (Linn. f.) is a small to medium sized deciduous tree, which belongs to the family Fabaceae. It is widely distributed in the tropical regions of the world. The plant has significant importance in traditional medicine for its ethnomedicinal value. The plant is mainly used to cure the skin ailments, oral diseases, cough, pyrexia, diarrhoea, dysentery, hyper nervous activity and also used as a potent anti-hemorrhagic, anti-inflammatory, anti-bacterial, anti-cancer and hepatoprotective agent. Phytochemical investigations have revealed that P. santalinus contains triterpenes, flavones, coumarins, tannins, phenolic acids, polysterols and essential oils. The active constituents of P. santalinus include alpha and beta santalol, Cedrol, pterocarpol, isopterocarpol, santalin A, B, pterocarpin, cryptomeridiol and santalin. The plant can be investigated for pharmacological activities as it has high medicinal value. The review discusses the antimicrobial, antioxidant, cytotoxicity and hepatoprotective activity of P. santalinus .
Keywords Pterocarpus santalinus Bioactive compounds Medicinal plants Phytochemicals Secondary metabolites
References Arnone A, Camarda L, Merlini L, Nasini G (1975) Structures of the red sandalwood pigments santalins A and B. J Chem Soc Perkin Trans 1:186–194. doi:
10.1039/p 19750000186
CrossRef Google Scholar Arokiyaraj S, Martin S, Perinbam K, Marie Arockianathan P, Beatrice V (2008) Free radical scavenging activity and HPTLC finger print
Pterocarpus santalinus L.-an in vitro study. Indian J SciTechnol 1:1–3
Google Scholar Arunakumara KK, Walpola BC, Subasinghe S, Yoon M-H (2011)
Pterocarpus santalinus Linn. f. (Rathhandun): a review of its botany, uses, phytochemistry and pharmacology. J Korean Soc Appl Biol Chem 54(4):495–500
Google Scholar Azamthulla M, Balasubramanian R, Kavimani S (2013) Acute and subacute toxicity of
Pterocarpus santalinus heartwood extracts in rats. Int J Front Sci Technol 1(3):99–113
Google Scholar Cho JY, Jisoo Park AB, Pyoung S, Kim ESY, Baik KU (2001) Savinin, a lignan from
Pterocarpus santalinus inhibits tumor necrosis factor-a production and T cell proliferation. Biol Pharm Bull 24(2):167–171
PubMed CrossRef Google Scholar Dhanabal P, Kannan SE, Bhojraj S (2007) Protective and therapeutic effects of the Indian medicinal plant
Pterocarpus santalinus on D-galactosamine-induced liver damage. Asian J Trad Med 2:51–57
Google Scholar Hutchinson J, Dalziel JM, Keay RWJ (1958) Floral of west tropical Africa. Agents Overseas Gov Adm London 1:531
Google Scholar Kameswara Rao B, Giri R, Kesavulu MM, Apparao C (2001) Effect of oral administration of bark extracts of
Pterocarpus santalinus L. on blood glucose level in experimental animals. J Ethnopharmacol 74(1):69–74
PubMed CrossRef Google Scholar Kesari AN, Gupta RK, Watal G (2004) Two aurone glycosides from heartwood of
Pterocarpus santalinus . Phytochemistry 65:3125–3129
PubMed CrossRef Google Scholar King FE, Cotterill CB, Godson DH, Jurd L, King TJ (1953) The chemistry of extractives from hardwoods. Part XIII. Colourless constituents of Pterocarpus species. J Chem Soc 3693–3697
Kole PL et al (2005) Cosmetics potential of herbal extracts. Nat Prod Radiance 4(4):315–321
Google Scholar Kondeti VK, Badri KR, Maddirala DR, Thur SK, Fatima SS, Kasetti RB, Rao CA (2010) Effect of
Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats. Food ChemToxicol 48(5):1281–7
CrossRef Google Scholar Krishnamoorthy (2011) Free radical scavenging and antibacterial evaluation of
Pterocarpus santalinus l eaf in vitro study. IJPSR 2(5):1204–1208
Google Scholar Krishnaswamy NR, Sundaresan CN (2012) Fascinating organic molecules from nature 1.Some exotic red pigments of plant origin. Reson 17(11):928–942
CrossRef Google Scholar Krishnaveni KS, Srinivasa Rao JV (2000) A new isoflavoneglucoside from
Pterocarpus santalinus . Asian Nat Prod Res 2:219–223
CrossRef Google Scholar Kumar D (2011) Anti-inflammatory, analgesic, and antioxidant activities of methanolic wood extract of
Pterocarpus santalinus L. J Pharmacol Pharmacother 2(3):200–202
PubMedCentral PubMed CrossRef Google Scholar Kumar N, Ravindranath B, Seshadri TR (1974) Terpenoids of
Pterocarpus santalinus heartwood. Phytochem 13:633–636
CrossRef Google Scholar Kwon HJ, Hong YK, Kim KH, Han CH, Cho SH, Choi JS, Kim BW (2006) Methanolic extract of
Pterocarpus santalinus induces apoptosis in HeLa cells. J Ethnopharmacol 105(1–2):229–34
PubMed CrossRef Google Scholar Liu CH, Zou XW, Lu H, Tan RX (2001) Antifungal activity of artemisia annuaendophyte cultures against phyto- pathogenic fungi. J Biotechnol 88:277–82
PubMed CrossRef Google Scholar Manjunatha BK (2006a) Antibacterial activity of
Pterocarpus santalinus . Indian J Pharm Sci 68:115–116
CrossRef Google Scholar Manjunatha BK (2006b) Hepatoprotective activity of Pterocarpus santalinus L.f., an endangered medicinal plant. Indian J Pharmacol 38(1):25–28
CrossRef Google Scholar Manjunatha BK, Rupani AR, Priyadarshini P, Paul K (2010) Lead finding from
Pterocarpus santalinus with hepatoprotective potentials through
insilico methods. Int J Pharma Sci Res 1(7):265–270
Google Scholar Narayan S, Devi RS, Srinivasan P, Shyamala Devi CS (2005)
Pterocarpus santalinus : a traditional herbal drug as a protectant against ibuprofen induced gastric ulcers. Phytother Res 19(11):958–62
PubMed CrossRef Google Scholar Narayan S, Devi RS, Devi CSS (2007) Role of
Pterocarpus santalinus against mitochondrial dysfunction and membrane lipid changes induced by ulcerogens in rat gastric mucosa. ChemBiolInterac 170:67–75
Google Scholar Okigbo RN, Eme UE, Ogbogu S (2008) Biodiversity and conservation of medicinal and aromatic plants in Africa. Biotechnol Mol Biol Rev 3:127–134
Google Scholar Okuda T, Ito H (2011) Tannins of constant structure in medicinal and food plants- hydrolyzable tannins and polyphenols related to tannins. Mol 16:2191–2217
CrossRef Google Scholar Rahman MM, Khan MA (2013) Anti-cancer potential of South Asian plants. Nat Prod Bioprospecting 3:74–78
CrossRef Google Scholar Raju KK, Nagaraju A (1998) Geobotany of red sanders (
Pterocarpus santalinus )-a case study from the southeastern portion of Andra Pradesh. Environ Geol 37:340–345
CrossRef Google Scholar Rane, Gramarc ND (1998) Hepatoprotective activity of
Pterocarpus marsupium and Buteakoen-ex-Roxb. Indian J Pharm Sci 5:182–184
Google Scholar Rao SP, Raju AJS (2002) Pollination ecology of the red sanders
Pterocarpus santalinus (Fabaceae), an endemic and endangered tree species. CurrtSci India 83:1144–1148
Google Scholar Rao BK, Giri R, Kesavulu MM, Apparao C (2001) Effect of oral administration of bark extract of
Pterocarpus santalinus L. on blood glucose level in experimental animals. J Ethnopharmacol 74:69–74
CrossRef Google Scholar Rudd VE (1991) In: A Revised Handbook of the Flora of Ceylon. CRC Press, Boca Raton, pp 108–381
Google Scholar Saleem M (2009) Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett 285(2):109–115. doi:
10.1016/j.canlet.2009.04.033
PubMedCentral PubMed CrossRef Google Scholar Sandrine P (2006) Pterocarpuserinaceus; State of Forest Genetic Resources in the Sahelian and Northern Sudanian Zone of Africa (FAO)
Shou-Fang W, Chang F-R, Wang S-Y (2011) Anti-inflammatory and cytotoxic neoflavonoids and benzofurans from
Pterocarpus santalinus . J Nat Prod 74:989–996
CrossRef Google Scholar Strobel G, Daisy B (2003) Bioprospecting for Microbial endophytes and their natural products. Microbiol Mol Biol Rev 67:491–502
Thakur M, Melzig MF, Fuchs H, Weng A (2011) Chemistry and pharmacology of saponins: special focus on cytotoxic properties. Botanics Targets Ther 1:19–29
Google Scholar Vandita P, Amin N, Khyati P, Monisha K (2013) Effect of phytochemical constituents of
Ricinus Communis ,
Pterocarpus santalinus ,
Terminalia Belerica on antibacterial, antifungal and cytotoxic activity. Int J Toxicol Pharmacol Res 5(2):47–54
Google Scholar Varma RR, Vijayamma N (1991) Pharmacological studies on rakthachandana. J Res Ayurved Sidd 12:190–199
Google Scholar Verma S, Singh SP (2008) Current and future status of herbal medicines. Vet World 1(11):347–350
CrossRef Google Scholar Wu SF, Chang FR, Wang SY, Hwang TL, Lee CL, Chen SL, Wu CC, Wu YC (2011) Anti-inflammatory and cytotoxic neoflavonoids and benzofurans from
Pterocarpus santalinus . J Nat Prod 74:989–996
PubMed CrossRef Google Scholar © Institute of Korean Medicine, Kyung Hee University and Springer Science+Business Media Dordrecht 2014
Authors and Affiliations 1. Department of Studies in Microbiology University of Mysore Mysore India