Inhibition of chemokine, interleukin-8 expression in an atopic milieu by Pyeongwee-San extract (KMP6)

Se-Eun Jin; Phil-Dong Moon; Jong-Ho Koh; Hun-Sun Lim; Hyung-Min Kim; Hyun-Ja Jeong

doi:10.1007/s13596-011-0004-8

Oriental Pharmacy & Experimental Medicine

March 2011, 11:71

Inhibition of chemokine, interleukin-8 expression in an atopic milieu by Pyeongwee-San extract (KMP6)

Authors
Authors and affiliations

Se-Eun Jin
Phil-Dong Moon
Jong-Ho Koh
Hun-Sun Lim
Hyung-Min Kim
Hyun-Ja JeongEmail author

Research Article

First Online:: 24 March 2011

Received:: 07 December 2010
Accepted:: 04 January 2011

DOI: 10.1007/s13596-011-0004-8

Cite this article as:: Jin, SE., Moon, PD., Koh, JH. et al. Orient Pharm Exp Med (2011) 11: 71. doi:10.1007/s13596-011-0004-8

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Abstract

Interleukin (IL)-8 (CXCL8) expression has been found to be increased in mast cells in atopic dermatitis. It is the most important chemoattractant for immune cells. Pyeongwee-San is a traditional Korean medicine which has been using as a useful prescription for treatment of atopic dermatitis. The objective of this study was to determine precisely the effect of Pyeongwee-San extract (KMP6) on IL-8 expression using human mast cell line, HMC-1 cells. KMP6, HS-Pyeongwee-San (HS-PS, an over-the-counter drug of the Han Kook Shin Yak Pharmaceutical Co., LTD.), and the important component of KMP6, hesperidin inhibited the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced IL-8 secretion and mRNA expression in HMC-1 cells. These effects were better than those of dexamethasone, the reference drug tested in our experimental model. Our results revealed the effect of KMP6, which may act as a promising therapeutic agent for the treatment of atopic dermatitis.

Keywords

Pyeongwee-San (KMP6) Chemokine Interleukin-8 Atopic dermatitis

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Authors and Affiliations

Se-Eun Jin
- 1
Phil-Dong Moon
- 1
Jong-Ho Koh
- 2
Hun-Sun Lim
- 3
Hyung-Min Kim
- 1
Hyun-Ja Jeong
- 4
Email author

1.Department of Pharmacology, College of Oriental MedicineKyung Hee UniversitySeoulRepublic of Korea
2.Department of Bio-Food AnalysisKorea Bio-polytechnic CollegeNonsan-siRepublic of Korea
3.Korea Medi Co., Ltd.SeoulRepublic of Korea
4.Biochip Research CenterHoseo UniversityAsanRepublic of Korea

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Inhibition of chemokine, interleukin-8 expression in an atopic milieu by Pyeongwee-San extract (KMP6)

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